Increasingly, people who work outside of the nonprofit world are pursuing long-held dreams of starting a charity to attempt to solve many of the world's most intractable problems.

But establishing one's own nonprofit organization is not easy, and often presents a set of challenges not usually found in the business world. So how do you set up a charity? What are the toughest obstacles? And how are these new charities and the people who establish them changing the philanthropic landscape?

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