Holden Karnofsky isn’t afraid to challenge nonprofit groups and foundations through The GiveWell Blog.

On Tuesday, the 26-year-old former who worked in the hedge-fund world is offering Chronicle of Philanthropy readers the opportunity to challenge him.

Mr. Karnofsky is the founder of GiveWell, an organization devoted to evaluating charities, as well as the Clear Fund — a philanthropy he calls “the world’s first transparent grant maker” — to demonstrate how he and his colleagues think foundations should operate.

The Clear Fund, now in the process of awarding about $140,000 in grants, asks its grant applicants to provide hard evidence that they are effective. It publishes its assessment of that evidence on the GiveWell Web site, whether it decides the group is worthy of support or not.

On Tuesday at noon Eastern time, Mr. Karnofsky will answer readers’ questions during a live discussion. The forum is open to everyone, not just Chronicle subscribers.

Readers are invited to submit a question to Mr. Karnofsky, who will answer those queries during a one-hour discussion.

And he says on his blog that he expects challenging questions.

“I type 120wpm, I am beyond pumped to have an online
chat with the nonprofit sector, I want to take on all comers, and if
it ends up being an hour of softball questions like “Do you think
the nonprofit sector would benefit from more transparency?” I’m
going to blame you,” he wrote in a recent post on The GiveWell Blog.