The trust of the late hotel queen Leona Helmsley is donating $25-million to establish a center for heart-disease research at New York’s Mount Sinai Medical Center, The Wall Street Journal says.

The Leona M. and Harry B. Helmsley Charitable Trust Cardiovascular Translational Research Center will work to speed the development of new drugs, devices, and protocols to treat heart disease, which claimed Ms. Helmsley, her father, her son, and a sister.

The trust, to which Ms. Helmsley left most of her estimated $4-billion estate, focuses on health and medical research. The new gift follows last year’s $37.5-million donation to Mount Sinai, with which the hospital established centers for electrophysiology and inflammatory-bowel disease.

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