Nike co-founder Phil Knight and his wife, Penny, have donated $125-million to Oregon Health & Science University to launch a cardiovascular research center, reports The Oregonian. The gift is the largest in the university’s history.

The contribution, announced Monday, is the Knights’ second nine-figure gift to the school in four years, topping the $100-million the couple donated in 2008 for improvements at the OHSU Cancer Center, now the OHSU Knight Cancer institute.

As it did with that gift, the university will use the latest Knight donation to attract top surgeons and scientists to the school, in this case to study cardiovascular health and test drugs and devices to treat and protect against stroke, clogged arteries, and high blood pressure.

“We would like to be one of the top five [cardiovascular] institutions in the country,” said Dr. Albert Starr, who will co-direct the new facility.