The Burnham Institute for Medical Research, in La Jolla, Calif., has received a $50-million gift from T. Denny Sanford, the South Dakota mogul’s second major donation to the facility, reports The San Diego Union-Tribune.

In 2007 Mr. Sanford gave $20-million to the center, which has now been renamed the Sanford-Burnham Medical Research Institute. The new money will support institute programs that are not eligible for government grants, with a focus on turning the facility’s research into real-world applications.